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What is it?

Amyloid fibrils are protein polymers comprising identical monomer units (homopolymers). Functional amyloids play a beneficial role in a variety of physiologic processes (eg, long-term memory formation, gradual release of stored peptide hormones). Amyloidosis results from the accumulation of pathogenic amyloids—most of which are aggregates of misfolded proteins—in a variety of tissues. 

Amyloidosis is a rare disease that may happen because of an abnormal protein called amyloid and affects the functions of other important organs. This may affect the heart, kidney, liver, and spleen.

What is it?

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Amyloid fibrils are protein polymers comprising identical monomer units (homopolymers). Functional amyloids play a beneficial role in a variety of physiologic processes (eg, long-term memory formation, gradual release of stored peptide hormones). Amyloidosis results from the accumulation of pathogenic amyloids—most of which are aggregates of misfolded proteins—in a variety of tissues. 

Amyloidosis is a rare disease that may happen because of an abnormal protein called amyloid and affects the functions of other important organs. This may affect the heart, kidney, liver, and spleen.

Causes

  • Hereditary
  • Long term dialysis
  • Inflammatory disease like Rheumatoid Arthritis.

Treatment

  • Chemotherapy
  • Heart medications
  • Targeted therapies
  • Autologous blood stem cell transplant
  • Dialysis
  • Organ transplant

Symptoms

  • Swelling of your ankles and legs
  • Severe fatigue and weakness
  • Shortness of breath with minimal exertion
  • Unable to lie flat in bed due to shortness of breath
  • Numbness, tingling or pain in your hands or feet, especially pain in your wrist (carpal tunnel syndrome)
  • Diarrhea, possibly with blood, or constipation

Risk Factors

  • For the inherited forms of amyloidosis are being genetically related to an ancestor with the disease
  • For the secondary amyloidosis are the underlying inflammatory chronic medical conditions.
  • Age over 60 years old.
  • Male gender

Causes

  • Hereditary
  • Long term dialysis
  • Inflammatory disease like Rheumatoid Arthritis.

Treatment

  • Chemotherapy
  • Heart medications
  • Targeted therapies
  • Autologous blood stem cell transplant
  • Dialysis
  • Organ transplant

Symptoms

  • Swelling of your ankles and legs
  • Severe fatigue and weakness
  • Shortness of breath with minimal exertion
  • Unable to lie flat in bed due to shortness of breath
  • Numbness, tingling or pain in your hands or feet, especially pain in your wrist (carpal tunnel syndrome)
  • Diarrhea, possibly with blood, or constipation

Risk Factors

  • For the inherited forms of amyloidosis are being genetically related to an ancestor with the disease
  • For the secondary amyloidosis are the underlying inflammatory chronic medical conditions.
  • Age over 60 years old.
  • Male gender